CALL FOR PAPERS Comparative Genomics Dietary iron-deficient anemia induces a variety of metabolic changes and even apoptosis in rat liver: a DNA microarray study

نویسندگان

  • Asuka Kamei
  • Yuki Watanabe
  • Tomoko Ishijima
  • Mariko Uehara
  • Soichi Arai
  • Hisanori Kato
  • Yuji Nakai
  • Keiko Abe
چکیده

Asuka Kamei, Yuki Watanabe, Tomoko Ishijima, Mariko Uehara, Soichi Arai, Hisanori Kato, Yuji Nakai, and Keiko Abe Food Safety and Reliability Project, Kanagawa Academy of Science and Technology, Takatsu-ku, Kawasaki, Kanagawa; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Tokyo; Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Setagaya-ku, Tokyo; and Corporate Sponsored Research Program “Food for Life” (Nestlé), Organization for Interdisciplinary Research Projects, University of Tokyo, Bunkyo-ku, Tokyo, Japan

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Dietary iron-deficient anemia induces a variety of metabolic changes and even apoptosis in rat liver: a DNA microarray study.

Anemia can be induced by dietary iron deficiency, as well as by hemorrhagia. It may also be associated with changes in lipid metabolism. However, no global analysis detailing the consequences of iron deficiency in the liver has yet been conducted. Since the liver is a metabolically important organ and also a major iron-storing organ, we performed a comprehensive transcriptome analysis to determ...

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Influence of a Short-Term Iron-Deficient Diet on Hepatic Gene Expression Profiles in Rats

Iron is an essential mineral for the body, and iron deficiency generally leads to anemia. However, because non-anemic iron deficiency can exist, we performed a comprehensive transcriptome analysis of the liver to define the effects of this condition on the body. Four-week-old male rats were fed a low-iron diet (approximately 3 ppm iron) for 3 days and compared with those fed a normal diet (48 p...

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Ichthyotoxic Cochlodinium polykrikoides Induces Mitochondrial Mediated Oxidative Stress and Apoptosis in Rat Liver Hepatocytes

In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes were obtained by collagenase perfusion of Sprague-Dawley rat liver.According to our results, incubation of algal...

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تاریخ انتشار 2010